afraidofsurgery
Well-known member
Has anyone experienced a drug-drug interaction with an oral contraceptive? I have been on Ortho Evra since a few years prior to my surgery. It's now a few years after my aortic valve replacement surgery with a mechanical valve.
My coumadin dose has been raised slowly to accomodate my PT-INR readings. My cardio says this is not unusual. I started out on 7.5 mg/day 6 days/week; 10 mg/d 1 day/wk, and now it's 10 mg/d 5 days/wk; 7.5 mg/d 2 days/wk. But this is not my problem.
Seems after the dose increase to 10 mg/d 3 days/wk; 7.5 mg/d 4 days/wk, I've experienced spotting and bleeding, along with an extended period (2 weeks - yuk!) where I haven't before. As some may understand, this is more annoying to me than the open heart surgery was
I searched pubmed for drug-drug interactions with oral contraceptives but didn't find anything pertinent. Of course these problems could be due to something unrelated and I will be making an appt with my ob/gyn. But wanted to check if I missed anything in the literature about perhaps the coumadin causing increased metabolism of the ortho evra so it's effectieness is decreased.
Thanks!!
Patty
My coumadin dose has been raised slowly to accomodate my PT-INR readings. My cardio says this is not unusual. I started out on 7.5 mg/day 6 days/week; 10 mg/d 1 day/wk, and now it's 10 mg/d 5 days/wk; 7.5 mg/d 2 days/wk. But this is not my problem.
Seems after the dose increase to 10 mg/d 3 days/wk; 7.5 mg/d 4 days/wk, I've experienced spotting and bleeding, along with an extended period (2 weeks - yuk!) where I haven't before. As some may understand, this is more annoying to me than the open heart surgery was
I searched pubmed for drug-drug interactions with oral contraceptives but didn't find anything pertinent. Of course these problems could be due to something unrelated and I will be making an appt with my ob/gyn. But wanted to check if I missed anything in the literature about perhaps the coumadin causing increased metabolism of the ortho evra so it's effectieness is decreased.
Thanks!!
Patty