#### pellicle

##### Professional Dingbat, Guru and Merkintologist

Hi

I read this recently

https://pubmed.ncbi.nlm.nih.gov/17296877/

From that:

so basically stop using your bottle, have a pill box, set an alarm and take your damn pills.

No wonder surgeons keep pushing bio-prostheses ... at least the risks are back in the surgeons hands.

Its in your hands ...

I read this recently

https://pubmed.ncbi.nlm.nih.gov/17296877/

From that:

*Among 136 participants observed for a mean of 32 weeks, 92% had at least 1 missed or extra bottle opening; 36% missed more than 20% of their bottle openings; and 4% had more than 10% extra bottle openings. In multivariable analyses, there was a significant association between underadherence and underanticoagulation. For each 10% increase in missed pill bottle openings, there was a 14% increase in the odds of underanticoagulation (P<.001); participants with more than 20% missed bottle openings (1-2 missed days each week) had more than a 2-fold increase in the odds of underanticoagulation (adjusted odds ratio, 2.10; 95% confidence interval, 1.48-2.96). Participants who had extra pill bottle openings on more than 10% of days had a statistically significant increase in overanticoagulation (adjusted odds ratio, 1.73; 95% confidence interval, 1.09-2.74).*

**

**Conclusion:**Patients have substantial difficulties maintaining adequate adherence with warfarin regimens, and this poor adherence has a significant effect on anticoagulation control.so basically stop using your bottle, have a pill box, set an alarm and take your damn pills.

No wonder surgeons keep pushing bio-prostheses ... at least the risks are back in the surgeons hands.

Its in your hands ...

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