A
alan_delac
Hi,
I gave myself task to find out what happened with development of synthetic valve described in this article:
http://www.csiro.au/index.asp?type=mediaRelease&id=McLennanAward2002
After a fair bit of fruitless search I was given E-mail address of Dr Ian Griffiths and he was very helpful in providing update on this valve. Here is copy of our correspondence. I'm afraid you'll have to read from the bottom up.
Here it is:
Hi Alan
The concept valve has been tested in adult and juvenile sheep. In both models the sheep had no anticoagulation and the valve did very well. In one of those models some manufacturing and leaflet design issues were highlighted. These have now been resolved, but we are back to the partner running functional animal work.
So to answer your question at this stage we believe the valve has the potential to be used without anticoagulation therapy but the proof is yet to be firmly established.
Regards
Ian
Ian,
Thank you for the response. I would like to ask you just one more question. Has this heart valve been tested on animals? Bovine model is of particular interest as it would give a good indication if anticoagulation would be required with this heart valve.
Regards
Alan
Thank you for the offer, but the groups we are dealing with are the large medical device companies. So lobbying will not really help out too much in this scenario.
Again thanks
Ian
Dear Ian
Thank you for your e-mail.
Valvereplacement.com is now a substantial community. Is there something we could do to help the development process? Maybe we could generate some interest by sending a lots of questions even like potential investors.
Regards
Alan
Hello Alan
It is not a bother, thank you for the e-mail.
The situation right now is that AorTech has ceased direct investment in the synthetic valve program. However the program was at a suitably mature stage that we envisage a partner with the financial might to endure the clinical trial process will be found. At that time we will make announcements on our web site and communicate the next steps for approval.
In my opinion this technology remains as the leading edge of synthetic valve replacement, hence my optimism for it's introduction to the marketplace.
Please feel free to contact me in future
Regards
Ian
Dear Dr. Griffiths
Sorry to bother you but any news on the heart valve developments is very important to a large number of people in my situation.
I have bicuspid aortic valve and will have to replace the valve sometimes in the next 3-10 years. I am member of valvereplacement.com forum dedicated to support of heart valve patients and their families.
As all of the current medical solutions for this condition have disadvantages we are keenly following the latest developments in the hart valve technologies.
Any information you could provide on development of the heart valve mentioned in this CSIRO article (http://www.csiro.au/index.asp?type=mediaRelease&id=McLennanAward2002) would be greatly appreciated.
Dr. Gunatillake provided your Email address.
Best regards
Alan Delac
I gave myself task to find out what happened with development of synthetic valve described in this article:
http://www.csiro.au/index.asp?type=mediaRelease&id=McLennanAward2002
After a fair bit of fruitless search I was given E-mail address of Dr Ian Griffiths and he was very helpful in providing update on this valve. Here is copy of our correspondence. I'm afraid you'll have to read from the bottom up.
Here it is:
Hi Alan
The concept valve has been tested in adult and juvenile sheep. In both models the sheep had no anticoagulation and the valve did very well. In one of those models some manufacturing and leaflet design issues were highlighted. These have now been resolved, but we are back to the partner running functional animal work.
So to answer your question at this stage we believe the valve has the potential to be used without anticoagulation therapy but the proof is yet to be firmly established.
Regards
Ian
Ian,
Thank you for the response. I would like to ask you just one more question. Has this heart valve been tested on animals? Bovine model is of particular interest as it would give a good indication if anticoagulation would be required with this heart valve.
Regards
Alan
Thank you for the offer, but the groups we are dealing with are the large medical device companies. So lobbying will not really help out too much in this scenario.
Again thanks
Ian
Dear Ian
Thank you for your e-mail.
Valvereplacement.com is now a substantial community. Is there something we could do to help the development process? Maybe we could generate some interest by sending a lots of questions even like potential investors.
Regards
Alan
Hello Alan
It is not a bother, thank you for the e-mail.
The situation right now is that AorTech has ceased direct investment in the synthetic valve program. However the program was at a suitably mature stage that we envisage a partner with the financial might to endure the clinical trial process will be found. At that time we will make announcements on our web site and communicate the next steps for approval.
In my opinion this technology remains as the leading edge of synthetic valve replacement, hence my optimism for it's introduction to the marketplace.
Please feel free to contact me in future
Regards
Ian
Dear Dr. Griffiths
Sorry to bother you but any news on the heart valve developments is very important to a large number of people in my situation.
I have bicuspid aortic valve and will have to replace the valve sometimes in the next 3-10 years. I am member of valvereplacement.com forum dedicated to support of heart valve patients and their families.
As all of the current medical solutions for this condition have disadvantages we are keenly following the latest developments in the hart valve technologies.
Any information you could provide on development of the heart valve mentioned in this CSIRO article (http://www.csiro.au/index.asp?type=mediaRelease&id=McLennanAward2002) would be greatly appreciated.
Dr. Gunatillake provided your Email address.
Best regards
Alan Delac
