Pretty soon OHS will be like a NASCAR pit stop- all good for the pt. if it proves out:
http://www.biospace.com/news_story.cfm?StoryID=18723020&full=1
http://www.biospace.com/news_story.cfm?StoryID=18723020&full=1
Journal of the American College of Cardiology Volume 43 said:Recent advances in stent and valve technologies have demonstrated that percutaneous valve replacement is feasible in both animals and humans. The integration of a bioprosthetic valve and a stent was first demonstrated by Andersen et al. in 1992 [6] in which a porcine bioprosthesis attached to a wire-based stent was delivered at various aortic sites with satisfactory acute hemodynamic results. Since then, several other investigators have reported the implantation by catheter delivery techniques of prosthetic valves of various designs in animal models [7, 8, 9, 10 and 11]. The first clinical cases of percutaneous valve replacement in congenital heart disease were reported by Bonhoeffer et al. [12 and 13], who successfully implanted prosthetic heart valves made from bovine jugular vein and mounted onto a platinum-iridium stent and placed in stenotic right ventricle to pulmonary conduits with good immediate and long-term results.
Journal of the American College of Cardiology Volume 43 said:Paravalvular aortic regurgitation was noted in all patients post-PHV implantation. Echocardiography indicated that there might be imperfect apposition of the PHV stent frame against the diseased native valvular structures at the site of calcific nodules. This was confirmed on postmortem observation in Patient 3 (Fig. 3). Although paravalvular aortic regurgitation did not blunt the early improvement in left ventricular function and clinical status after relief of the aortic valve blockage, severe paravalvular aortic regurgitation might impair long-term clinical outcomes after PHV implantation. Larger maximal stent diameters and other improvements in stent design might decrease the incidence and severity of paravalvular aortic regurgitation in the future.
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