Ton, what is your weekly dose right now? And what is your range? What has your INR been lately?
The following is all "If it were me" thoughts. Everyone is different and 15 years of Coumadin use allow me to know what my body does with dosage changes.
so If it were me:
I wouldn't skip a dose, I probably wouldn't change my dose. I'd most likely just keep it the same and retest in a week. But my range is 2.5-3.5
If my previous INR's showed that is had been getting higher, I'd probably do a 10% reduction, or maybe even just a 5%.
Remember, the more Coumadin you take the faster your INR will drop. I take 70/week.
Has something changed lately, such as your activity level? If you usual get some physical exercise and you haven't been able to lately, then I'd just leave the dose alone if you were going to be getting back to the activity level.