I did an advance search for statin and studies, and a few post came up here is one that has some of the info http://www.valvereplacement.com/forums/showthread.php?t=7446&highlight=statin+studies
Anyone hear of Statins for calcification??
- Thread starter Lorimacm
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I did an advance search for statin and studies, and a few post came up here is one that has some of the info http://www.valvereplacement.com/forums/showthread.php?t=7446&highlight=statin+studies
Reddog
Well-known member
Perhaps the Latest Study
Perhaps the Latest Study
Not sure if this one of the studies referred to above, but here's a Fall 2008 article from the New England Journal of Medicine indicating that statins have not been effective at dealing with aortic stenosis due to calcification.
http://content.nejm.org/cgi/content/full/359/13/1395?ijkey=f2a5a8ce1afbab9ea44058ea332439a3011621c6&keytype2=tf_ipsecsha
A few key quotes:
"The key initiating factor in the development of calcific aortic stenosis appears to be mechanical stress."
"We can no longer reassure ourselves that either the lipid-lowering or pleiotropic effects of potent agents such as statins and ezetimibe might change the disease process in the valve leaflets.....Calcific aortic stenosis is not atherosclerosis."
Sorry... I wish statins were the key... I'd be taking them if they were.
Reddog
Valve-Sparing Ascending Aorta Replacement, BAV, 6/11/09
Perhaps the Latest Study
Not sure if this one of the studies referred to above, but here's a Fall 2008 article from the New England Journal of Medicine indicating that statins have not been effective at dealing with aortic stenosis due to calcification.
http://content.nejm.org/cgi/content/full/359/13/1395?ijkey=f2a5a8ce1afbab9ea44058ea332439a3011621c6&keytype2=tf_ipsecsha
A few key quotes:
"The key initiating factor in the development of calcific aortic stenosis appears to be mechanical stress."
"We can no longer reassure ourselves that either the lipid-lowering or pleiotropic effects of potent agents such as statins and ezetimibe might change the disease process in the valve leaflets.....Calcific aortic stenosis is not atherosclerosis."
Sorry... I wish statins were the key... I'd be taking them if they were.
Reddog
Valve-Sparing Ascending Aorta Replacement, BAV, 6/11/09
