Foldax Continues

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Humboldtgrrl

Well-known member
Joined
Mar 22, 2021
Messages
45
Thanks for this update & Link (with other great articles, as well). My sister had an opportunity to be in their KS trials earlier & declined. Hope things continue to go well for the clinical participants. We owe a lot to trial participants
 
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jlcsn2015

Liborio
Joined
Sep 20, 2015
Messages
246
Location
Toronto
This may be the path to the future of mech-valves-end, at least makes more sense to me than tissue valves that will be attacked by design by the human immune system no matter who says what, a foreing tissue is a foreign tissue; I wish it was no the case, i would have chosen tissue valve instead of OnX, but it is what it is; and for me what was important 7 years ago it was-is Not to have a second OPS due to Valve Failure; That is my perspective do not want to be right, and as per guinea pig offers.... Hmmm no thank you, i know what the South Africans did to get first heart transplant, it was not nice....
 

Warrick

Well-known member
Joined
Dec 26, 2015
Messages
760
Location
New Zealand
This would suggest cardiovascular calcification is an immune response-

“Cardiovascular calcification is regulated through an integrated combination of innate and adaptive immune responses”
“Immunomodulatory drugs possess the potential to target and treat calcification.”
 

pellicle

Professional Dingbat
Joined
Nov 4, 2012
Messages
10,079
Location
Queensland, OzTrayLeeYa
Tissue valves don't get "attacked" by the immune system. Where did you get that idea?
Perhaps here:

Mechanisms underlying SVD are incompletely understood, and early concepts suggesting the purely degenerative nature of this process are now considered oversimplified. Recent studies implicate the host immune response as a major modality of SVD pathogenesis, manifested by a combination of processes phenocopying the long‐term transplant rejection, atherosclerosis, and calcification of native aortic valves​
 

ATHENS1964

Well-known member
Joined
Oct 19, 2019
Messages
300
First Patients Outside of U.S. Treated with TRIA Biopolymer Surgical Aortic Heart Valve in India Clinical Trial

 

pekster11

Well-known member
Joined
Apr 20, 2011
Messages
233
Location
Chester, UK
First Patients Outside of U.S. Treated with TRIA Biopolymer Surgical Aortic Heart Valve in India Clinical Trial

Looks promising
I'd imagine it won't be known for decades how well this copolymer valve holds up in the human body
 
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