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Marty

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New blood thinners may compete with warfarin, but they're not perfect drugs

By Marie McCullough
Tuesday, January 5, 2010;



Warfarin, one of the most inconvenient, dangerous and disliked drugs in the world, has remained vitally important for more than 50 years.

That tells you how much difficulty scientists have had coming up with safer, easier pills to do what warfarin does: fight life-threatening blood clots.

Now, at long last, better oral blood thinners are on the horizon. In July, the Food and Drug Administration approved Effient to prevent clots in patients undergoing angioplasty to unblock a coronary artery. The maker of Brilinta plans to seek FDA approval for use in such patients by year's end.

Next in the race for the FDA's imprimatur may be Xarelto and Rendix; both were recently approved in Europe for clot prevention in orthopedic-surgery patients. At least five other clot-fighters are in late stages of development, all eager to tap the estimated $20 billion global market for such drugs.

The hope is that, with more choices and less hassle, doctors can tailor therapy to patients' needs. Surgery, heart disease, faulty heart valves, cancer treatment: any of these can make short-term or long-term clot-fighting crucial. So can the abnormal heartbeat called atrial fibrillation, which puts an estimated 2.2 million Americans at elevated risk of stroke. In a study published in August, Rendix became the first drug to show benefits over warfarin in atrial fibrillation patients.

And unlike warfarin, Rendix does not need constant monitoring and dosage adjustment. "The characteristics of [Rendix] are so much more user-friendly than warfarin," said cardiologist Michael D. Ezekowitz, vice president of clinical research at Main Line Health System in suburban Philadelphia and a leader of international Rendix studies.

Still, the new blood thinners have minuses as well as pluses, and they won't come cheap. Physicians may also be reluctant to change long-established practices involving warfarin, which began its long history as a rat poison.

Geno J. Merli, who has tested many of the new entrants as director of the vascular disease center at Philadelphia's Thomas Jefferson University Hospitals, called them promising but said their value in real-life practice remained to be seen. ''We're all looking for a replacement for warfarin," Merli said. "But these new drugs are not the panacea." Until now, the only oral blood thinners besides warfarin have been Plavix (clopidogrel), the world's second-best-selling drug, and aspirin, the over-the-counter pain reliever.

Tinkering with the clotting system is dicey because it maintains an exquisitely complex balance. It keeps the circulating blood fluid yet instantly congeals a bit of blood at just the right spot to plug an injured vessel. Injury or irritation signals disk-shaped blood cells called platelets to morph into star shapes and interlock at the site of damage. Then a cascade of clotting factors, culminating with the enzyme thrombin, overlays a sticky mesh that catches passing red blood cells and knits the whole plug together.

Platelets dominate the clotting process in the arteries, while the thrombin pathway dominates in the veins. This also complicates the therapeutic challenge because, depending on where the drug disrupts this system, it may help one patient but not another.

Plavix, for example, inhibits platelet action, so it is good at retarding clots in arteries. These clots often form on top of fatty plaque, the hallmark of heart disease, and block the artery. That can trigger painful angina or a full-blown heart attack.

But Plavix, made by Sanofi-aventis, is not as good as warfarin against clots in veins deep in the legs or pelvis, the kind that typically develop after surgery. These tiny clumps can travel to the lungs or the brain, with devastating consequences. Brilinta, made by AstraZeneca, also inhibits platelets, but it's faster and stronger than Plavix. In a recently published study, Brilinta was slightly better than Plavix at preventing heart attack, stroke and cardiovascular death in patients hospitalized with chest pain.

Even so, the FDA is sure to scrutinize a risk inherent in blood thinners: bleeding. Both Brilinta and Plavix caused life-threatening or disabling bleeding in about 11 percent of patients; Brilinta had higher rates of less serious bleeding than Plavix.

Daniel Hoffman, president of Pharmaceutical Business Research Associates, a consulting firm in Glenmoore, Pa., said, "The FDA has pretty much signaled to [drugmakers] that where there are available therapies, unless you can show a substantial clinical benefit that advances the standard of care, the FDA is going to have a very low risk tolerance." Bleeding risk may chill interest in Effient (prasugrel), a platelet inhibitor made by Eli Lilly and Daiichi Sankyo. Although Effient was more effective than Plavix at preventing heart attacks and strokes in angioplasty patients, it increased fatal bleeding.

The FDA required Effient's label to carry a "black box" warning about the bleeding risks.

Although warfarin, also sold as Coumadin, costs only about $160 a year, it is not cheap therapy. Patients require frequent blood tests to check clotting time and dosage, because warfarin's potency can be affected by certain drugs, dietary supplements, genetic variations and Vitamin K-laden vegetables. Problems with warfarin are the most common reason for emergency-room visits by older adults, according to the Centers for Disease Control and Prevention.
 
Interesting but I still don't see any replacement for Coumadin happening in my lifetime.

What I don't understand, instead of throwing all this money on studies is, why don't they educate the doctors in proper dosing and such. Seems to me, that would be better spent money and the so called dangerous Coumadin drug wouldn't be so dangerous. Why do they insist on blaming the drug?
 
A very informative read, thanks Marty. I know how hard it will be to form a test group of patients with mechanical valves for any new "blood thinner". Still, I'm glad there is so much research going on in this area since it affects so very many people. I too doubt that a real warfarin replacement will be in use in my lifetime....at least for valve patients. Thanks again for posting it. It is a very good article.
 
Interesting but I still don't see any replacement for Coumadin happening in my lifetime.

What I don't understand, instead of throwing all this money on studies is, why don't they educate the doctors in proper dosing and such. Seems to me, that would be better spent money and the so called dangerous Coumadin drug wouldn't be so dangerous. Why do they insist on blaming the drug?

Ross, I asked one of my hematologists why he was so uncomfortable with warfarin and why they were working so hard on a replacement. This is what he said-I took notes." warfarin has many adverse properties. Vit K varies widely in foods. Warfarin inhibits the synthesis of sequential enzymes in the coagulation cascade which imparts a drastically steep dose-response relationship. The binding of warfarin to plasma proteins and its metabolism by cytochrome P-450 enzymes facilitate drug interactions. These properties result in variability in anticoagulant control which is associated with bleeding, thrombosis, and death." Otherwise warfarin is an OK drug.

I think these thrombin inhibitors will first be used short term after hip and knee replacements, in angioplasty, etc. After more study , in a-fib. Then after many years with new and better inhibitors maybe us mechanical valvers.
 
I just find it interesting that I over heard about this "replacement" at the lab last week. A gentleman was chatting to another fellow about INR and this 'replacement' his doctor had told him about.

What's really amazing is that this news is floating around my city in Canada - where we (Canada) is usually the last to find out about these things - little-own to implement it.
 
I just find it interesting that I over heard about this "replacement" at the lab last week. A gentleman was chatting to another fellow about INR and this 'replacement' his doctor had told him about.

What's really amazing is that this news is floating around my city in Canada - where we (Canada) is usually the last to find out about these things - little-own to implement it.

Be proud! Freddie, Mc Master University in Hamilton Ontario has the world authorities in hematology and anticoagulation. I think the first thrombin inhibitor was discovered there.
 
..........
What's really amazing is that this news is floating around my city in Canada - where we (Canada) is usually the last to find out about these things - little-own to implement it.

Canada is just as advanced as the rest of America, but the government is much slower to approve new drugs, especially when the new drugs are to replace long term proven ones.
(My Montreal surgeon has already done successful percutaneous AVR.):)
 
Ross, I asked one of my hematologists why he was so uncomfortable with warfarin and why they were working so hard on a replacement. This is what he said-I took notes." warfarin has many adverse properties. Vit K varies widely in foods. Warfarin inhibits the synthesis of sequential enzymes in the coagulation cascade which imparts a drastically steep dose-response relationship. The binding of warfarin to plasma proteins and its metabolism by cytochrome P-450 enzymes facilitate drug interactions. These properties result in variability in anticoagulant control which is associated with bleeding, thrombosis, and death." Otherwise warfarin is an OK drug.

No offense meant Marty, but sometimes I think Doctors over analyze things in their minds rather then try common sense approaches. What I'm saying is, we didn't go to school to learn about the clotting cascades or all the clotting factors or anything else, but we understand this drug where they don't seem too.
 
Ross, I asked one of my hematologists why he was so uncomfortable with warfarin and why they were working so hard on a replacement. This is what he said-I took notes." warfarin has many adverse properties. Vit K varies widely in foods. Warfarin inhibits the synthesis of sequential enzymes in the coagulation cascade which imparts a drastically steep dose-response relationship. The binding of warfarin to plasma proteins and its metabolism by cytochrome P-450 enzymes facilitate drug interactions. These properties result in variability in anticoagulant control which is associated with bleeding, thrombosis, and death." Otherwise warfarin is an OK drug.

Sounds like he was quoting from a textook and has memorized his response. But then, Marty, you're a doctor. Wonder what he would have said to a layperson?
 
gobbeldey-gook?

gobbeldey-gook?

Marsha, Unfortunately this is the way these people talk. I think he pretended I was one of his board examiners. I'm not sure what they tell the patients. Most of the patients I see deal with the pharmacists who run our anticoagulation program and are very happy with them. I agree with Ross- you can make this too hard.
 
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