Marcumar/Phenprocoumon vs Warfarin

[tommyboy14]

Hi all,

Anglosaxon countries tend to use warfarin as the anticoagulant of choice.

But most other developed nations use Marcumar/Phenprocoumon.

Marcumar stays for a lot longer in your system (longer half life), so apparently INR can be very stable.

Does anybody know why anglosaxon countries seem to prefer Warfarin over Marcumar?

Thanks
Tommyboy

PS. I am asking because if Marcumar were to be clearly superior, I would consider asking my GP to let me switch

 

[pellicle]

Does anybody know why anglosaxon countries seem to prefer Warfarin over Marcumar?

half life makes management easier and "withdrawl" for therapies easier (Elimination half-life is 6–7 days instead of more like 2 for warfarin).

Accordingly, something like this would be impossible under Phenprocoumon
https://cjeastwd.blogspot.com/2022/05/rapid-dust-off-inr-management.html

further I think the effect of taking Grapefruit would take longer to subside.

Also unlike (say) Sintrom you aren't INR=1 the day after your forgot your dose.

Personally I feel that warfarin is the not too hot and not too cold, the Goldilocks anticoagulant.

you can imagine that in reality they're going to rip her to shreds when they get into the house

;-)

HTH

 

[Protimenow]

This reminded me to look up the Darwin Awards - if they're still giving them.