I am familiar with alot of the detoxs out there. I think they usually are a good idea! With that said, one on coumadin would have to be careful of them. If you do them, I would recommend not sticking with the "usual dose". Go slowly-read this once again-slowly with the brand you choose. It should affect the INR. Done slowly should produce good results but not create havoc to your body suddenly and make your blood levels go crazy.Don't sacrifice a "clean organs inside" detox idea with bringing your INR too low/high and the side effects from it.