Warfarin and gout

[Martin1962]

I'm recovering well after ohs in January to replace mitral valve with mechanical, albeit with a few complications along the way. The latest thing is that I've now been diagnosed with high uric acid levels causing gout and a kidney stone. Not sure if there's a connection - has anyone else had this problem since taking warfarin?

 

[pellicle]

Not sure if there's a connection

found this:

Warfarin administration increases uric acid concentrations in plasma - PubMed

The effect of warfarin administration on plasma uric acid was investigated. A representative sample of patients on long-term warfarin treatment had a significantly higher concentration of uric acid in plasma than did age-matched patients with comparable plasma urea concentrations who were not...

pubmed.ncbi.nlm.nih.gov

published 1986

Abstract​

The effect of warfarin administration on plasma uric acid was investigated. A representative sample of patients on long-term warfarin treatment had a significantly higher concentration of uric acid in plasma than did age-matched patients with comparable plasma urea concentrations who were not taking warfarin. In women, this association was observed only in patients with normal values for plasma urea, not in those with high values. In contrast, in men this association was present in both groups (normal and high plasma urea). In a longitudinal study involving patients, their plasma uric acid significantly increased after warfarin administration. There was no significant change in the renal clearance of uric acid after a single dose of warfarin in normal, healthy volunteers; this contrasts with the increase observed with other coumarin anticoagulants. Our findings suggest that the increase in plasma uric acid noted with warfarin administration is probably due to an increase in uric acid production and may predispose to gout those patients who are on long-term therapy with warfarin.​

so not good news there ... but then again only findings of correlation

... however also found this:

Lack of effect of warfarin on uric acid concentration - PubMed

Uric acid concentrations reportedly are increased in patients being treated with warfarin. We measured uric acid in 40 patients before and during warfarin administration. The mean pre- and post-warfarin uric acid concentrations for our patients were 0.39 mmol/L and 0.40 mmol/L, respectively, not...

pubmed.ncbi.nlm.nih.gov

published in 1988

Abstract​

Uric acid concentrations reportedly are increased in patients being treated with warfarin. We measured uric acid in 40 patients before and during warfarin administration. The mean pre- and post-warfarin uric acid concentrations for our patients were 0.39 mmol/L and 0.40 mmol/L, respectively, not a significant difference. Further observations of hyperuricemic patients started on warfarin are needed to prove that their risk of gout is not increased.​

so its not really conclusive IMO

HTH

 

[tom in MO]

I've had kidney and bladder stones, but warfarin was not blamed for them. Per my urologist, the only effect warfarin has on that part of your body is you will have more blood in your urine if other things are going wrong (e.g. bladder stone, cancer, etc..) Warfarin increases the visible symptom but is not the cause.

 

[pekster11]

Yes
Last summer and this summer during my workplace medical, my Uric acid levels were elevated (491umol/l) and my ATL/GPT liver enzyme as well (65 IU/l)

I've been wondering if warfarin could be the cause of this ?

 

[tom in MO]

Yes
Last summer and this summer during my workplace medical, my Uric acid levels were elevated (491umol/l) and my ATL/GPT liver enzyme as well (65 IU/l)

I've been wondering if warfarin could be the cause of this ?

Ask your doctor. Warfarin is a common drug whose effects have been studied for years and thus are well-characterized.