A study conducted by the team of Dr. Jean-Claude Tardif, Director of the Research Centre at the Montreal Heart Institute (MHI), has led to the discovery of a new approach to treat aortic valve stenosis through the administration of a compound that prevents valve deterioration and can even reverse the progression of the disease.
This study conducted in mice suffering from aortic valve stenosis showed successful outcomes with infusions of a compound that mimics HDL (high-density lipoprotein), which is often referred to as "good cholesterol." This treatment could help open narrowed aortic valves, avoid the major complications of aortic valve stenosis (including the need for heart surgery), and prevent heart failure and sudden death.
These results are extremely encouraging, as they allow us to hope that this type of treatment will work for people who suffer from aortic valve stenosis. If so, it will represent a brand-new treatment option that may even prevent open-heart surgery to replace valves damaged by stenosis," said Dr. Jean-Claude Tardif. "This treatment may be an alternative to a procedure that is complex, risky and very invasive for patients."
In this study, mice were put on a cholesterol-enriched diet until aortic valve stenosis was detected using echocardiography (a medical imaging ultrasound system used in humans). The animals were then divided into two groups: a control group that received saline infusions and a treatment group that received infusions of a compound that mimics good cholesterol (an apoA-I mimetic peptide) for two weeks. These results were particularly impressive as, after only 28 days of treatment, the aortic valve opened more fully in the treatment group compared to the control group. The aortic wall in the treatment group had also reduced in thickness compared to the control group.
Furthermore, microscopic analysis also revealed that the extent of the scar lesions (or accumulated collagen) in the valves was significantly smaller in the treated subjects than in the control subjects
http://www.sciencedaily.com/releases/2013/07/130718101242.htm
This study conducted in mice suffering from aortic valve stenosis showed successful outcomes with infusions of a compound that mimics HDL (high-density lipoprotein), which is often referred to as "good cholesterol." This treatment could help open narrowed aortic valves, avoid the major complications of aortic valve stenosis (including the need for heart surgery), and prevent heart failure and sudden death.
These results are extremely encouraging, as they allow us to hope that this type of treatment will work for people who suffer from aortic valve stenosis. If so, it will represent a brand-new treatment option that may even prevent open-heart surgery to replace valves damaged by stenosis," said Dr. Jean-Claude Tardif. "This treatment may be an alternative to a procedure that is complex, risky and very invasive for patients."
In this study, mice were put on a cholesterol-enriched diet until aortic valve stenosis was detected using echocardiography (a medical imaging ultrasound system used in humans). The animals were then divided into two groups: a control group that received saline infusions and a treatment group that received infusions of a compound that mimics good cholesterol (an apoA-I mimetic peptide) for two weeks. These results were particularly impressive as, after only 28 days of treatment, the aortic valve opened more fully in the treatment group compared to the control group. The aortic wall in the treatment group had also reduced in thickness compared to the control group.
Furthermore, microscopic analysis also revealed that the extent of the scar lesions (or accumulated collagen) in the valves was significantly smaller in the treated subjects than in the control subjects
http://www.sciencedaily.com/releases/2013/07/130718101242.htm
