yes, it doesDoes anyone know if grapefruit interacts with warfarin?
this may helpIt is something the grapefruit that lessens the effects of Warafrin(Coumadin),
And stay away from Green tea also, it affects the way warafrin works.this may help
Grapefruit juice decreases the activity of the cytochrome P450 3A4 (CYP3A4) enzymes that are responsible for breaking down many drugs and toxins. Grapefruit contains compounds known as furanocoumarins that block the CYP3A4 enzymes. When grapefruit juice is consumed, the enzyme’s ability to break down the drug for elimination is decreased. Blood levels of the drug may rise, resulting in the risk for new or worsened side effects.
so basically good old P450 again ;-)