This may be the path to the future of mech-valves-end, at least makes more sense to me than tissue valves that will be attacked by design by the human immune system no matter who says what, a foreing tissue is a foreign tissue; I wish it was no the case, i would have chosen tissue valve instead of OnX, but it is what it is; and for me what was important 7 years ago it was-is Not to have a second OPS due to Valve Failure; That is my perspective do not want to be right, and as per guinea pig offers.... Hmmm no thank you, i know what the South Africans did to get first heart transplant, it was not nice....