Blood pressure medications and coronaviruses

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DDT77

Well-known member
Joined
Dec 9, 2017
Messages
54
Location
NC, USA
Hi All,

We know that different blood pressure medications work in different manners. We've also heard that Covid-19, and coronaviruses in general may use ACE2 pathway to gain entry to human cells, and replicate. There have been implications that medications that up-regulate (such as ARBs and ACE inhibitors) ACE2 expression that may allow for Covid-19 in particular to overwhelm our defenses. Are there blood pressure (or other) medications that down-regulate ACE2 expression, as the natural action of this pathway is diminished, such the entryway for this uninvited guest is mitigated?
I found this snippet "While ACE2 activity in blood samples of DCM patients without beta blockers is potent in correlating with the severity of disease and in predicting death and heart transplant, its correlation and prediction potency are significantly diminished by beta blocker treatment."
https://www.researchgate.net/publication/265135967_Beta_Blockers_Prevent_Correlation_of_Plasma_ACE2_Activity_With_Echocardiographic_Parameters_in_Patients_With_Idiopathic_Dilated_Cardiomyopathy
Article is completely unrelated to Covid-19, but could premise be reasonable?

Thoughts?
 

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