It seems natural at this point, no?
personally (as a person with a bent towards Environmental Science and Sustainable sorts of studies) the whole idea of "Natural" gets pretty hard to associate with people and human activities since agriculture, and is amplified in subsequent ages.
I've been a cyborg for over 10 years but before that had 2 surgeries which have essentially delayed my death (first one when I was 10yo). Indeed my mother survived peritonitis from a ruptured appendix in her teens because of the newly invented penicillin drug administration.
I ride a motorcycle, drive a car, have electricity in my constructed house ... not much of my life is natural.
heck, now I'm even dependent on a drug if I want to live longer (probably two or three really).
Just an alternative perspective ;-)
Keep on tikkin