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The Cymbalta threads are old, so I thought I would share. I had a steady Warfarin dose of 7.5mg/day and steady INR around 2.5. Started taking Cymbalta, INR shot to 3.1. Reduce the dosing, but continued to taper up the Cymbalta. Two weeks later INR of 3.9. So I am again reducing the Warfarin...

Sweet Jesus I did not need to see that.

I got mine last April so... I have no idea why it was sent now. Advertising I suspect. I want to see the post-FDA approval data before I ask for a lower INR target. (Currently 2.5.)

I got this in the mail, telling me to "take this postcard with you to discuss this information with your physician." Anyone else get this? No link to the study behing the FDA approval, no discussion of the risks from dropping the target INR. Why advertise On-X to a doctor who already uses On-X...

My wife reached out to a world-renowned heart surgeon before mine, and he said "this is a big deal for you but it is a very routine procedure for the surgeon." He was right, my surgeon knew exactly how long the surgurey would take, what he would find, how it would be dealt with. Recovery takes a...

And don't forget to add all the details to your signature. Gotta get the street cred!

I bought those exact socks that @pellicle has on his post. They work fine, not too tight. Not quite the same level as the premium compression socks but a heck of a lot cheaper. You can buy a few. Easier to get on as well. Recommend, easily worth the cost to see if they work for you.

For joints I am a big fan of Glucosamine. Maybe get the Tumeric compound version, since I'm guessing you don't get a lot of spice in your fine Irish cuisine. (blood sausage anyone?...)

Fish oil interaction with warfarin - PubMed Seems like it can be a thing for some people. Now be aware that this study covers exactly 1 patient, so keep it in context.

I second trying melatonin before bed. I wish warfarin made me bulk out... You could try taking the warfarin first thing after waking up. See if it makes a difference. Let us know.

The second test was to see if alchohol in the bloodstream was the issue. Worth an 8$ to find out.

I took my INR today stone cold sober. 3.7 again. Time to eat some kale dammit.

Took my INR and it was 3.7 instead of my usual 2.5-3.0. I had a healthy vodka lemonade an hour before. Would alcohol actively in the blood affect the reading? I don't want to start adjusting my dosage if I was just a dumb ass. Thoughts? Experience?

God, grant me the serenity to accept the things I cannot change, the courage to change the things I can, and the wisdom to know the difference.

Canoeing the Canadian shield.

I guess nobody studies/evaluates these things in high-performance situations. They only take measurements on people who are lying down on a table. The results of such a study would have altered my choice, knowing that valve A performs 10% better than valve B when hiking/riding/running.

to add to Pellicle's list, try Melatonin before bed. I find it helps me, and it's about as safe as it gets.

I had ultrasounds for years before I got to surgery. One of the benefits of multiple ultrasounds is that they can see progression. Is it getting worse or is it stable? Big difference in how you treat it.

I was in the same place as you, but strangely enough I was not nervous. I think it was because I'd spent so long waiting for the operation and the symptoms were coming on heavy that I was able to accept the surgery as the only sensible course of action. As for the warfarin lifestyle it's not so...