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Hi all, Anglosaxon countries tend to use warfarin as the anticoagulant of choice. But most other developed nations use Marcumar/Phenprocoumon. Marcumar stays for a lot longer in your system (longer half life), so apparently INR can be very stable. Does anybody know why anglosaxon countries...

Hi Everyone, I hope that all of the wise people here can help me with the following. and when I say help, I mean did you experience something like this before? - It seems that after intensive exercise (going at 150bps for 40 minutes on the cross trainer), I now get some degree of mental...

https://www.novostia.com/sites/default/files/inline-files/Novostia%20-%20Press%20Release%20-%20September%202023.pdf According to the release, they will implant the first trileaflet mechanical valve, which should in theory and animal models not require warfarin, in a human in December 2023...

Hello, a lot of people on the forum who are about to undergo surgery always ask about rate of complications, etc. The US STS just came up with a new risk calculator: https://acsdriskcalc.research.sts.org/ You can play with it yourself to get your numbers. Of course this should never be...

Hi Team, Although the Proact Xa trial failed, it looks like there are now new Anticoagulants on the horizon which cause less bleeding. They are only in clinical trials now, so we will not know for a couple of years how they even compare to Apixaban. However, if this comes through, I wouldnt be...

Hello team, does anyone have experience with how paracetamol (Tylenol) affects your INR? My INR recently jumped from 2.1 to 3.1 within four days after I started taking paracetamol for tooth ache. Did anyone else have a similar experience? Thanks Tommy

Hi Team, I came across this great website to make evidence appraisal easy for clinicians: NERDCAT They also have an interesting analysis of the ON-X valve PROACT trial: https://nerdcat.org/studysummaries/proact They say (the bold is from their analysis, ie not me): Based on the 95% CI, the...

Hi Team, The PROSE trial, a randomised control trial between ON-X and St Jude valves, have now published their results. https://www.sciencedirect.com/science/article/pii/S2666273622003084 From the abstract: The total patient population (N = 855) included patients receiving an On-X valve (n =...

Hi Team, I am looking for something wearable (wrist preferably) that will help me measure heart rate, Heart rate variability while I sleep and how many steps per day. In an ideal world also tells the time. I am interested in a device that does these four things well. I couldnt care less about...

Hi Team, I just had my On-X valve installed on May 12th. I was on Amiodiorone unti June 18th, and now my only med is warfarin. I have started my dose out of hospital with 4mg a day, but am now up to 10mg a day. Even though the anti-coag clinic keep raising my intake, it seems very hard to get...

Professor Hans Sievers (Now retired, but used to be Germany's Ross procedure expert and one of the leading surgeons in that country) is working on new trileaflet mechanical valve. They first tested in in a lab: https://pubmed.ncbi.nlm.nih.gov/30590696/ Now they have shown you can put in sheep...

Hello everybody, I figured I would share my story. I have been reading this forum for years off and on. I am now 3 months post my 2nd AVR. I had the first one at 33 in 2014. At the time I was choosing between Ross, tissue and mechanical. Ross went out the window since one of the best (in...

Hello there, the discussion with most surgeons and from reading this forum, it seems that the only choice one has is between a Tissue vs Mechanical valve (excluding the RP). But it seems that there are also Homografts. Somehow this seems to have gone out of fashion, but from the study that...

Hello, can you have a bloodclot event or bleeding when your INR is in range? I was under the impression that so long the INR is in range nothing can happen, butbreadimg this board seems like You could have an event even with the INR in range. is that right? Thanks tommyboy

Hello, I was recently diagnosed with BAV, am 33 and am stil thinking about the choice of Ross versus mechanical valve. Are the different mechanical valve's (St Jude's Regents, ATS or OnX) diffferent i ntheir tendency to produce bloodclots given the same INR? I.e. are there any studies who have...

Hello, I was recently diagnosed with severe aortic stenosis and regurgitation (actually a month ago). The funny thing that I am quite an active guy, am 33 and have never ever felt any symptomps. I used to do ski racing when I was in college and my wife and I regularly Ski/ DO long hikes, etc. I...