Recent content by henkac

Hi Mr V. Our daughter had OHS three days after her birth. She had transposition, interrupted aortic arch, a leaking aortic valve and vsd. We also found out during a standard ultra sound and I can fully relate to the thoughts and emotions you and your family is going through. She's 15 now and...

Yes, that's probably it. Thanks for helping me out with reflecting.

Reading and analyzing research data on a daily basis has been a part of my job for the last 15 years so I feel pretty at home. (Not about heart valves and warfarin though.) The more you learn, the more humble you get too however, due to understanding how often you make mistakes and how little...

Lowering IT and Proact is strictly looking at Mechanical valves. The dutch also includes Atrial Fibrillation and Myocardial Infarction (majority of patients). It wouldn´t be fair or give us any valuable information to compare LowIT and Proact to something different then they try to answer...

Dutch: 483 patiens for 1.149 p-years (Mec Valve) Lowering IT: 396 patients for 2.217 p-years Proact: 375 patients for 1.426 p-years

I wouldn't discharge the age difference in age as of low significance. Lowering IT mean age 49, Proact 55. The dutch is not giving us a clear mean age but viewing how they diveded age groups it's clear it's a significant older population. Specially since most research would say risk of events...

The tabel you posted above is this, right? Being used in thus study from the Netherlands: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/415179 So I assumed it to be "the dutch stud". Hope I'm not totalt out of bounds here 🙂

https://pubmed.ncbi.nlm.nih.gov/20598989/ It's the Lowering IT study you linked to in your earlier post regarding the 1:3 ratio.

You mean 26 events per 100 patient years, right? If you refer to "The dutch study". Or am I missing something? Also note: out of the 38 total bleeding events, 11 is "Nonfatal bleeding in skin and muscles". They adopted the event labeling from an even older study and "Nonfatal bleeding in skin...

This is actually numbers from the Lowering IT - study from 2010. No On-X there.

Yes. It tells us this is probably a bit more complex than we would wish it to be. We'de probably need to look at more individual factors on all of the patients to know what's really going on. You can also find in the study that both group have a couple of patient years below INR 1.5. I can't...

It's actually the other way around. They had 1 TE in the Low-INR and 3 in the standard.

Sad but probably true...

Wouldn't take any news channel as medical advice at all. 🙂 But still this is all you know about warfarin untill you start to research it. No wonder people fear it so much. Pro athletes (supermen) can bleed to death by a cut??? 😵‍💫

Good link. Thank you.