OK, so as I read the page after page about statin use, I must now table the whole beta blocker thing. The more I read about beta blockers, the more I have to wonder if they are right for me.
I was borderline hypertensive when I went into the hospital last year with a blocked RCA, and after discovering I had an aortic aneurism, I was placed on Metropolol. Now I have hard a lot of people out there who were placed on Hyzzar and Cozzar which are both ace inhibitors, not only for blood pressure regulation, but I am now seeing dozens of studies where Losartan (Cozzar) is being used to prevent the growth of aneurisms. There is a ton of compelling evidence out there showing that many folks who have participated in studies of this class of drugs are actually seeing a REDUCTION in size of aortic aneurisms.
Looking at the method in which all beta blockers act, there is furthermore, a lot of evidence that suggests that the use of ACE inhibitors like Metropolol combined with Statin drugs are producing long term heart failure patients. I am getting a good chunk of my research from a lot of sources but was extremely interested in studies by Dr Sinatra who has been looking at the "cocktail" of meds we are given when we leave the hospital after heart procedures, and years later return with high incidents of heart failure.
The acronym that keeps coming up is ATP (adenosine triphospate). THE HEART is an omnivore, able to oxidize a variety of substrates to support ATP production. Ace inhibitors and statin drugs inhibit the production of ATP as well as Coenzyme Q10 which we need to feed our body at the cellular level.
"Traditional treatments for chronic stable angina pectoris are aimed at increasing blood flow to the myocardium via coronary vasodilatation (eg, with nitrates), and at reducing the oxygen requirement of the ischemic tissue by decreasing heart rate, arterial blood pressure, and cardiac contractility (with ß-blockers, calcium channel antagonists, or nitrates). These hemodynamic approaches are effective at reducing anginal symptoms and improving exercise tolerance, but many patients continue to suffer from angina, despite optimal treatment with these drugs "
*William C. Stanley
Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University
I have read the work of a few Dr's like Stephen Sinatra (The Sinatra Solution) who concur with the assertion that ATP is vital to those of us who may be compromised through CAD, or a myriad of other afflictions of the cardio vascular system. Many forward thinking doctors have discovered that many of the traditional drugs we take like Ace Inhibitors and Statins rob our body of the ability to produce ATP and CoQ10. The result is damage to our muscle tissue at the cellular level, and as we all know, the heart is nothing but muscle.
Look, I could go on all night blowing this smoke folks. I certainly don’t have all the answers, and most doctors do not say to simply stop taking your statins or ace inhibitors, HOWEVER, some do! Some say supplementation with compounds like L carnatine, D ribose and CoQ10 are the answer IN ADDITION to the traditional drugs to keep the body producing ATP.
In addition to opening this up for discussion for those of you who are really acutely in touch with the drugs we put into our bodies and the negative effects of them balanced against the good they do, I am really curious if anyone else has reservations about the use of Beta Blockers and Statins in general?
I have some serious concerns about any drugs that screw with heart rate in a person who may have high blood pressure, but no heart rate issues. Sure, they are handing out metropolol like there is no tomorrow, but that’s because it’s cheap! Insurance companies love it vs. other types of drugs that do not mess with heart rate, but cost way more. I have read about people who went on drugs like Metropolol and simply could not stop taking it because it caused tremendous problems with uncontrolled heart rate in people who never had heart rate issues.
Mind you, I am not slamming on Metropolol, raving about Cozzar or pushing Dr. Sinatras book, BUT I am asking those of you who may share some concerns with drugs that alter heart rate where alteration of heart rate is not necessary (other than to reduce BP) where other drugs that could lower BP and leave the heart muscle alone could be used.
What’s your opinion? Has anyone out here read the work of Dr. Sinatra? How are your fairing on Metropolol? I know a lot of you are experiencing the lethargic aftereffects of Ace Inhibitors like I am, but the supplements DO help me. How about any of you?