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Thread: Warfarin and Tylenol

  1. #1
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    Question Warfarin and Tylenol

    Has anyone experienced with Extra Strength Tylenol's effect on INR?
    Mitral Valve Replacement Surgery, 1999
    Home test weekly since January 2004-Coaguchek S
    October 2006-Coaguchek XS
    INR managed by anti-coagulation clinic

  2. #2
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    None to my knowledge. I just know that you should not exceed the recommended dosage because you can screw your liver up.

    http://warfarinfo.com/New_Folder9/acetaminophen.htm

  3. #3
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    deleted - thought better of it. Ross covered it.
    BAV dx'd 10/08
    Ao enlargement dx'd 8/09
    SJM 25mm Master Grafted valve, lower aortic arch replacement 10/21/09 by D. Craig Miller, MD at Stanford University Hospital
    I am a VERY happy man.

  4. #4
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    Quote Originally Posted by lance View Post
    Has anyone experienced with Extra Strength Tylenol's effect on INR?
    Well not sure if there is a connection but......I've been having a low-grade headache everyday for about 2 weeks now & I take one X-stra strength Tylenol tablet almost daily to take it away. I checked my INR last night & it was 4.7. Last week it was 4.6, so I'm wondering.......
    Best Regards,
    N Jean

    May/1975: AVR & MVR -- St. Luke's, Houston TX (Denton Cooley, Surgeon)
    Dec/1975: MV Repair -- St. Luke's (Dr. Cooley)
    Mar/2006: AVR -- St. Luke's, Houston TX (George Reul, Surgeon)


    "Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less."
    - Marie Curie

  5. #5
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    Lance, are you talking about occasional use or more of a long term use?
    BAV-Aortic Stenosis...AVR Oct 11, 2005 / St.Jude Regent mechanical 21mm
    INR Home testing since 2007 with Coaguchek XS...Self-Dosing

    "Caution: I may have been in contact with Nuts"

  6. #6
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    I have been taken tylenol on fairly regular basis as I have been suffering from headaches for about a month almost daily. I just had my inr tested yesterday and it was at 2.66. So it doesn't seem to affect my inr but then everyone is different and it may affect others inr.
    Jackie


    rheumatic heart disease
    mitral valve replaced 5/29/09 st. jude mini 27 mm mechanical valve by Dr. Mihaljevic Cleveland Clinic
    pacemaker put it on 6/3/09
    Home testing with coaguchek XS since 1/16/2010

    just happy to be alive!

  7. #7
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    That's what they gave me in the hospital and continue to use it.

    I'd say, your good to go with no worries using Tylenol.
    Laughter is the Best Medicine

    MVR March 30/07 Carbomedics Valve - Said and done in 5 days - Shocked & Dumbfounded
    I've learned..That to ignore the facts does not change the facts

  8. #8
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    I had a 6.5 INR a few weeks ago and the only thing I had taken was hydrocodine.. a couple of days in a row I took 1 each day for a few things and my PT clinic said even though Tylenol is suggested over aspirin, that it does affect your PT/INR. This was the first I had heard of this though??
    Kristen - age 33
    ASD Repair - 1/1997 age 17(Dr. Ott St. Lukes in Houston)
    MV Repair 1/2000 age 20, 1 week later- MV Replacement - 1/2000 - St Jude's mechanical valve(Dr. Ott, THI at St. Lukes in Houston)
    3 yr old Son - BAV (Bicuspid Aortic Valve)
    twin girls - 2 months old through surrogacy

  9. #9
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    Quote Originally Posted by TXGal View Post
    I had a 6.5 INR a few weeks ago and the only thing I had taken was hydrocodine.. a couple of days in a row I took 1 each day for a few things and my PT clinic said even though Tylenol is suggested over aspirin, that it does affect your PT/INR. This was the first I had heard of this though??
    I do hope your not believing everything your clinic is telling you. You'd have to overdose on Tylenol for it to affect your INR.

    However, Hylek et al. found that if a person takes more than 26 regular- strength (325 mg each) or 19 extra-strength (500 mg each) over one week, the International Normalized Ratio (INR) may be raised. This will increase the chance of a person bleeding.

  10. #10
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    Default Thanks for commenting

    It's hard to know what to think. For several months my INR has been stable on a continuing dose of warfarin.

    Last week I injured my knee and took three 500 mgs XS Tylenol for two succesisve days followed by 1 tablet on day three. My INR went up 1 full point. Manager thinks Tylenol the culprit. Because my knee hurt so much I wasn't moving around, couldn't climb the stairs to the second floor where my computer is. I did have both flu shots at this time.

    I suppose should my INR unexpectedly drop Tylenol would shoot it up again.

    This is a hard one.

    Thanks for the help.
    Last edited by lance; November 7th, 2009 at 07:07 AM. Reason: accuracy
    Mitral Valve Replacement Surgery, 1999
    Home test weekly since January 2004-Coaguchek S
    October 2006-Coaguchek XS
    INR managed by anti-coagulation clinic

  11. #11
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    2 flu shots and not so much excercise is a great reason for INR to rise. That's what I'd be blaming anyhow.

  12. #12
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    Quote Originally Posted by Ross View Post
    I do hope your not believing everything your clinic is telling you. You'd have to overdose on Tylenol for it to affect your INR.
    No, I don't believe everything they say.. see, I thought it was strange she said that because I've been on coumadin 10 years and I have never been told that! This is why I'm trying to get my own machine at home.. the people at this clinic are driving me nuts! I don't agree at all with the way I've been regulated since moving here. Several years ago when I was at another clinic in another town, they were awesome and kept me regulated to a "T". This clinic, I could be way off the charts and they'll just say "Oh, stop your coumadin tonight (or increase if needed) and see you in a month"... that is just NOT right!
    Kristen - age 33
    ASD Repair - 1/1997 age 17(Dr. Ott St. Lukes in Houston)
    MV Repair 1/2000 age 20, 1 week later- MV Replacement - 1/2000 - St Jude's mechanical valve(Dr. Ott, THI at St. Lukes in Houston)
    3 yr old Son - BAV (Bicuspid Aortic Valve)
    twin girls - 2 months old through surrogacy

  13. #13
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    louisville, KY USA
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    I have taken 1000mg tylenol (two 500mg tabs) daily for about 5 years for spinal disc discomfort with little, or no, interference with INR.
    Starr-Edwards mechanical AVR 1967 at age 31.....University of Kentucky Med. Ctr., Dr. Richard Wood & Dr. Gordon Danielson surgeons. No surgery (heart or otherwise) since. On Warfarin ACT since surgery. No diet, lifestyle, or activity restrictions....and I live one day at a time.

  14. #14
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    Default Sorry folks

    Without a doubt the acetamoniphen has impacted my INR. Everyone is different. My INR has not been this unstable since I started home testing. So I Googled tylenol and warfarin and found many threads. One posted by the Cleveland Clinic was especially informing.

    Doses over 1500 mgs per day will raise INR levels just as I have been experiencing. 1500 mgs is within the recommended range for pain relief when using Tylenol ES or Tylenol/arthritis.

    So heads up when using 1500 mgs or more per day. 1500 mgs did nothing for the pain I was suffering so it was bad news from every perspective.
    Mitral Valve Replacement Surgery, 1999
    Home test weekly since January 2004-Coaguchek S
    October 2006-Coaguchek XS
    INR managed by anti-coagulation clinic

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