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Licorice and INR

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  • Licorice and INR

    I tested my INR this morning and the results were 4.2 and 4.7. I have pigged out on Licorice since Sunday. would this have any effect on my INR? This is the only thing I can think of that would be differant from my normal diet.
    [FONT="Comic Sans MS"][/FONT][COLOR="DarkOrchid"][/COLOR]
    Jackie
    AVR, April 6, 2006
    St Jude, Dr. Dennis Durzinsky
    Alta Bates Summit, Oakland, CA


    LIVE...as though Heaven is on Earth!
    DANCE...as though no one is watching!
    SING...as though no one can hear you!
    LOVE...as though today is your last![COLOR="DarkOrchid"][/COLOR]

    "Your treasure is always where your heart is" !!!!!!

  • #2
    I don't know about the INR effect, but licorice would mess up my heart rate, for sure.
    BAV-Aortic Stenosis...AVR Oct 11, 2005 / St.Jude Regent mechanical 21mm
    INR Home testing since 2007 with Coaguchek XS...Self-Dosing

    "Caution: I may have been in contact with Nuts"

    Comment


    • #3
      I haven't noticed anything difference in my heart rate, may I ask why it would effect heart rate?
      [FONT="Comic Sans MS"][/FONT][COLOR="DarkOrchid"][/COLOR]
      Jackie
      AVR, April 6, 2006
      St Jude, Dr. Dennis Durzinsky
      Alta Bates Summit, Oakland, CA


      LIVE...as though Heaven is on Earth!
      DANCE...as though no one is watching!
      SING...as though no one can hear you!
      LOVE...as though today is your last![COLOR="DarkOrchid"][/COLOR]

      "Your treasure is always where your heart is" !!!!!!

      Comment


      • #4
        Thank you, I will do that. Just thought I would try, I hate to call in my results because the anticoagulation pharmacist has a tizzy attach every time my INR is high.
        [FONT="Comic Sans MS"][/FONT][COLOR="DarkOrchid"][/COLOR]
        Jackie
        AVR, April 6, 2006
        St Jude, Dr. Dennis Durzinsky
        Alta Bates Summit, Oakland, CA


        LIVE...as though Heaven is on Earth!
        DANCE...as though no one is watching!
        SING...as though no one can hear you!
        LOVE...as though today is your last![COLOR="DarkOrchid"][/COLOR]

        "Your treasure is always where your heart is" !!!!!!

        Comment


        • #5
          Thank you Oaktree, I will look these up and least have something to tell the anticoagulation clinic.
          [FONT="Comic Sans MS"][/FONT][COLOR="DarkOrchid"][/COLOR]
          Jackie
          AVR, April 6, 2006
          St Jude, Dr. Dennis Durzinsky
          Alta Bates Summit, Oakland, CA


          LIVE...as though Heaven is on Earth!
          DANCE...as though no one is watching!
          SING...as though no one can hear you!
          LOVE...as though today is your last![COLOR="DarkOrchid"][/COLOR]

          "Your treasure is always where your heart is" !!!!!!

          Comment


          • #6
            Back before I had my own home monitor & was checking my INR at the Coumadin Clinic, the doctor told me NOT to eat licorice (the black kind) because it did interfere w/INR.
            Best Regards,
            N Jean (New Mexico)

            May/1975: AVR & MVR Double-Valves (Cooley-Cutter Mechanicals)
            Dec/1975: MV Repair -- Re-suture Mitral Mech. Valve (Dr. Denton Cooley)
            Mar/2006: AVR -- Old Valve Replaced w/St. Jude Mechanical (Dr. Reul)


            "Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less."
            - Marie Curie

            Comment


            • #7
              Thank you Norma, guess I have to learn the hard way. Nobody had ever mentioned that, and I love Black Licorice , since it was there I just had to eat it.
              [FONT="Comic Sans MS"][/FONT][COLOR="DarkOrchid"][/COLOR]
              Jackie
              AVR, April 6, 2006
              St Jude, Dr. Dennis Durzinsky
              Alta Bates Summit, Oakland, CA


              LIVE...as though Heaven is on Earth!
              DANCE...as though no one is watching!
              SING...as though no one can hear you!
              LOVE...as though today is your last![COLOR="DarkOrchid"][/COLOR]

              "Your treasure is always where your heart is" !!!!!!

              Comment


              • #8
                Well now I feel stupid. Of all the interactions listed, I never saw Licorice as one of them, but by golly google it and whammo. I think I'll go crawl back into my hole in the wall and pout.

                Comment


                • #9
                  Originally posted by Jackie View Post
                  I tested my INR this morning and the results were 4.2 and 4.7. I have pigged out on Licorice since Sunday. would this have any effect on my INR? This is the only thing I can think of that would be differant from my normal diet.
                  According to the prescribing leaflet for Coumadin, licorice contains coumarins, which would DECREASE your INR instead of increasing it.

                  So, no, I don't think the increase is related to your pigging out on licorice. (I love licorice, too!)

                  You might want to consider tweaking your dosage by 5-10% if you test in the 4.0-4.5 range again.
                  Marsha (7-28-50), MVP 1990/MVR (St. Jude) & ASD repair 6/24/03 Baylor University Medical Center, Dallas Texas. Hometesting since 11/03, first with ProTime 3, now with INRatio.
                  John (3-13-46), MV repair 5/10/07, Dallas Presbyterian, port-access incision, Dr. William Ryan. Chordae ruptured 12/05 in car crash.

                  Comment


                  • #10
                    I just found this...

                    Table 6 - Adverse Drug Effects/Drug Interactions of Selected Herbal or Food Products

                    Warfarin

                    Dashen - Increased anticoagulant activity or increased INR
                    Ginkgo biloba, garlic, feverfew, and cayenne - Platelet aggregation inhibitor effects and increased risk of bleeding/bruising
                    Ginseng (Siberian) - Decreased anticoagulant activity or decreased INR
                    Licorice - Increased anticoagulant activity or increased INR
                    Alfalfa - Decreased anticoagulant activity or decreased INR
                    Vitamin E (doses of 200 IU/day) - Increased anticoagulant activity and increased platelet aggregation inhibition, increased risk of bleeding
                    Ginger - Increased anticoagulant activity, increased INR, prolonged bleeding
                    Quinine - Increased anticoagulant activity or increased INR


                    http://www.uspharmacist.com/oldforma...teractions.htm

                    Comment


                    • #11
                      Originally posted by Susan BAV View Post
                      Table 6 - Adverse Drug Effects/Drug Interactions of Selected Herbal or Food Products

                      Warfarin

                      Dashen - Increased anticoagulant activity or increased INR
                      Ginkgo biloba, garlic, feverfew, and cayenne - Platelet aggregation inhibitor effects and increased risk of bleeding/bruising
                      Ginseng (Siberian) - Decreased anticoagulant activity or decreased INR
                      Licorice - Increased anticoagulant activity or increased INR
                      Alfalfa - Decreased anticoagulant activity or decreased INR
                      Vitamin E (doses of 200 IU/day) - Increased anticoagulant activity and increased platelet aggregation inhibition, increased risk of bleeding
                      Ginger - Increased anticoagulant activity, increased INR, prolonged bleeding
                      Quinine - Increased anticoagulant activity or increased INR


                      http://www.uspharmacist.com/oldforma...teractions.htm
                      Great site Susan! Thank you for providing the link to everyone!
                      Best Regards,
                      N Jean (New Mexico)

                      May/1975: AVR & MVR Double-Valves (Cooley-Cutter Mechanicals)
                      Dec/1975: MV Repair -- Re-suture Mitral Mech. Valve (Dr. Denton Cooley)
                      Mar/2006: AVR -- Old Valve Replaced w/St. Jude Mechanical (Dr. Reul)


                      "Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less."
                      - Marie Curie

                      Comment


                      • #12
                        This is from the Mayo Clinic, now I am confused:confused:

                        Search results
                        You searched for: interaction with licorice and warfarin
                        Results 1 - 1 of 1 are displayed
                        1.Warfarin side effects: Watch for dangerous interactions
                        Warfarin side effects are dangerous and put you at risk of heavy bleeding.
                        [FONT="Comic Sans MS"][/FONT][COLOR="DarkOrchid"][/COLOR]
                        Jackie
                        AVR, April 6, 2006
                        St Jude, Dr. Dennis Durzinsky
                        Alta Bates Summit, Oakland, CA


                        LIVE...as though Heaven is on Earth!
                        DANCE...as though no one is watching!
                        SING...as though no one can hear you!
                        LOVE...as though today is your last![COLOR="DarkOrchid"][/COLOR]

                        "Your treasure is always where your heart is" !!!!!!

                        Comment


                        • #13
                          Thank you all for your contributions, helping me find information on Licorice and Warfarin. Now I know I should not pig out on the black licorice that I love.
                          [FONT="Comic Sans MS"][/FONT][COLOR="DarkOrchid"][/COLOR]
                          Jackie
                          AVR, April 6, 2006
                          St Jude, Dr. Dennis Durzinsky
                          Alta Bates Summit, Oakland, CA


                          LIVE...as though Heaven is on Earth!
                          DANCE...as though no one is watching!
                          SING...as though no one can hear you!
                          LOVE...as though today is your last![COLOR="DarkOrchid"][/COLOR]

                          "Your treasure is always where your heart is" !!!!!!

                          Comment


                          • #14
                            If you love licorice (as do I), eat it regularly and it can be accounted for in your dosage. Why eliminate something you really enjoy if you can have moderate amounts of it and dose accordingly?

                            Comment


                            • #15
                              Originally posted by Oaktree
                              I don't have the prescribing leaflet. But with all due respect, coumarins are compounds that increase INR. Coumarins are chemically related to warfarin.

                              http://en.wikipedia.org/wiki/Coumarin
                              I stand corrected. I was almost dead tired when I typed that. I worked 7 days straight in the last week and haven't caught up on my beauty (and brain) rest. :D
                              Yes, it would have INCREASED the INR.

                              Seems like you'd really have to pig out on licorice to raise it that much, though.
                              Marsha (7-28-50), MVP 1990/MVR (St. Jude) & ASD repair 6/24/03 Baylor University Medical Center, Dallas Texas. Hometesting since 11/03, first with ProTime 3, now with INRatio.
                              John (3-13-46), MV repair 5/10/07, Dallas Presbyterian, port-access incision, Dr. William Ryan. Chordae ruptured 12/05 in car crash.

                              Comment

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