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Jackie
August 13th, 2008, 09:56 AM
I tested my INR this morning and the results were 4.2 and 4.7. I have pigged out on Licorice since Sunday. would this have any effect on my INR? This is the only thing I can think of that would be differant from my normal diet.

Bina
August 13th, 2008, 10:03 AM
I don't know about the INR effect, but licorice would mess up my heart rate, for sure.

Jackie
August 13th, 2008, 10:16 AM
I haven't noticed anything difference in my heart rate, may I ask why it would effect heart rate?

Jackie
August 13th, 2008, 10:31 AM
Thank you, I will do that. Just thought I would try, I hate to call in my results because the anticoagulation pharmacist has a tizzy attach every time my INR is high.

Jackie
August 13th, 2008, 12:30 PM
Thank you Oaktree, I will look these up and least have something to tell the anticoagulation clinic.

njean
August 13th, 2008, 12:40 PM
Back before I had my own home monitor & was checking my INR at the Coumadin Clinic, the doctor told me NOT to eat licorice (the black kind) because it did interfere w/INR.

Jackie
August 13th, 2008, 01:14 PM
Thank you Norma, guess I have to learn the hard way. Nobody had ever mentioned that, and I love Black Licorice , since it was there I just had to eat it.

Ross
August 13th, 2008, 01:19 PM
Well now I feel stupid. Of all the interactions listed, I never saw Licorice as one of them, but by golly google it and whammo. I think I'll go crawl back into my hole in the wall and pout.

catwoman
August 13th, 2008, 01:26 PM
I tested my INR this morning and the results were 4.2 and 4.7. I have pigged out on Licorice since Sunday. would this have any effect on my INR? This is the only thing I can think of that would be differant from my normal diet.

According to the prescribing leaflet for Coumadin, licorice contains coumarins, which would DECREASE your INR instead of increasing it.

So, no, I don't think the increase is related to your pigging out on licorice. (I love licorice, too!)

You might want to consider tweaking your dosage by 5-10% if you test in the 4.0-4.5 range again.

Susan BAV
August 13th, 2008, 01:41 PM
Table 6 - Adverse Drug Effects/Drug Interactions of Selected Herbal or Food Products

Warfarin

Dashen - Increased anticoagulant activity or increased INR
Ginkgo biloba, garlic, feverfew, and cayenne - Platelet aggregation inhibitor effects and increased risk of bleeding/bruising
Ginseng (Siberian) - Decreased anticoagulant activity or decreased INR
Licorice - Increased anticoagulant activity or increased INR
Alfalfa - Decreased anticoagulant activity or decreased INR
Vitamin E (doses of 200 IU/day) - Increased anticoagulant activity and increased platelet aggregation inhibition, increased risk of bleeding
Ginger - Increased anticoagulant activity, increased INR, prolonged bleeding
Quinine - Increased anticoagulant activity or increased INR


http://www.uspharmacist.com/oldformat.asp?url=newlook/files/feat/mar00druginteractions.htm

njean
August 13th, 2008, 01:43 PM
Table 6 - Adverse Drug Effects/Drug Interactions of Selected Herbal or Food Products

Warfarin

Dashen - Increased anticoagulant activity or increased INR
Ginkgo biloba, garlic, feverfew, and cayenne - Platelet aggregation inhibitor effects and increased risk of bleeding/bruising
Ginseng (Siberian) - Decreased anticoagulant activity or decreased INR
Licorice - Increased anticoagulant activity or increased INR
Alfalfa - Decreased anticoagulant activity or decreased INR
Vitamin E (doses of 200 IU/day) - Increased anticoagulant activity and increased platelet aggregation inhibition, increased risk of bleeding
Ginger - Increased anticoagulant activity, increased INR, prolonged bleeding
Quinine - Increased anticoagulant activity or increased INR


http://www.uspharmacist.com/oldformat.asp?url=newlook/files/feat/mar00druginteractions.htm

Great site Susan! Thank you for providing the link to everyone!:)

Jackie
August 13th, 2008, 01:45 PM
This is from the Mayo Clinic, now I am confused:confused:

Search results
You searched for: interaction with licorice and warfarin
Results 1 - 1 of 1 are displayed
1.Warfarin side effects: Watch for dangerous interactions
Warfarin side effects are dangerous and put you at risk of heavy bleeding.

Jackie
August 13th, 2008, 01:51 PM
Thank you all for your contributions, helping me find information on Licorice and Warfarin. Now I know I should not pig out on the black licorice that I love.

Jkm7
August 13th, 2008, 06:59 PM
:) If you love licorice (as do I), eat it regularly and it can be accounted for in your dosage. Why eliminate something you really enjoy if you can have moderate amounts of it and dose accordingly?

catwoman
August 14th, 2008, 06:55 AM
I don't have the prescribing leaflet. But with all due respect, coumarins are compounds that increase INR. Coumarins are chemically related to warfarin.

http://en.wikipedia.org/wiki/Coumarin

I stand corrected. I was almost dead tired when I typed that. I worked 7 days straight in the last week and haven't caught up on my beauty (and brain) rest. :D
Yes, it would have INCREASED the INR.

Seems like you'd really have to pig out on licorice to raise it that much, though.

allodwick
August 14th, 2008, 08:33 AM
Ross,
Crawl back out of your hole. I had forgotten about licorice, too.

catwoman
August 14th, 2008, 11:06 AM
Jackie:

Don't worry about trying to adjust your dosage to account for the increase in your INR.

UNLESS (drumroll here!) ... you plan to pig out on licorice daily from now on.

I love licorice jelly beans, gum drops, anything licorice! If it weren't for the residual black teeth :D, I'd eat it every day.
My bestest and closest friends are people who discard licorice anything. ;)

perrypiratesdad
August 14th, 2008, 11:10 AM
Dang it, I love Licorice (the black kind). Guess I have to have a spinach chaser with it now. O screw it, I'm not changing my eating habits now.

catwoman
August 14th, 2008, 01:32 PM
Dang it, I love Licorice (the black kind). Guess I have to have a spinach chaser with it now. O screw it, I'm not changing my eating habits now.

Should google for a recipe for a spinach & licorice quiche (yech!!!!!) :eek: ... That would balance everything out.

Jackie
August 14th, 2008, 03:10 PM
Thank you everyone, I will not stop eating Licorice, I will now what may have caused my INR to raise. I did go in for a lab test(because Kaiser makes me go if over 4.0) today and it came out just the same as my friend INRatio 4.2, so ha ha ha to the anticoagulation clinic, it was the same. They always tell me that my friend is not accurate. Thanks again dear people.:D

catwoman
August 14th, 2008, 07:51 PM
Jackie:

It's great that we can learn from others here.
What we learn gives us a real sense of power when we know why our INRs drop/increase. Knowledge lets things fall into place, instead of being continually being faced with one mystery after another.

No doubt most of us know more about warfarin and what affects it than the average medical professional!

aussigal
August 16th, 2008, 11:30 PM
What a coincidence to find this thread here today. My son and I just demolished a packet of black licorice and I never dreamt it would affect my INR so now I will delay testing for a few days and have a big bowl of green salad with dinner...yummo!

Jackie
August 17th, 2008, 10:49 AM
This would be a good test, why not test now and see if your INR increased? Let us know the results.

Ross
August 17th, 2008, 12:03 PM
This would be a good test, why not test now and see if your INR increased? Let us know the results.

Yeah really, I'd like to see what you just elevated yourself to myself. :)

aussigal
August 17th, 2008, 08:45 PM
Damn...I never thought of that....too late today...gotta be there before 10.30 am...For the sake of science I will buy some more licorice and indulge again before the end of the week and post the results! you got me wondering now too! and I also wonder how long it would take to have an effect and for how long this effect would last.

Ross
August 17th, 2008, 11:26 PM
Just be careful. Don't want you shooting up to 10.0 and start bleeding on us.

Jackie
August 18th, 2008, 08:47 AM
I would not eat more now, just thought if you could test right away it might show if it really does raise your INR........... Have a wonderful day.

Ross
August 18th, 2008, 09:53 AM
I would not eat more now, just thought if you could test right away it might show if it really does raise your INR........... Have a wonderful day.

I have no doubt that it does, question is, how much. :)

catwoman
August 18th, 2008, 11:09 AM
I can just see it now:

LICORICE --

the new rat poison.

For non-diabetic ;) rats, of course!

Susan BAV
August 18th, 2008, 04:11 PM
I can just see it now:

LICORICE --

the new rat poison.

For non-diabetic ;) rats, of course!I'm wondering if any of the various valve companies might want to develop any new test control anticoagulation study groups :D ...

aussigal
August 18th, 2008, 06:46 PM
OK, I been thinking!...to do this properly I would need to test oneday then come home and consume the licorice then go back and test the next day ( and no greens for dinner that night!)...so maybe this is more suited to someone who has a home test kit. I am quite willing to do it the other way but it will probably be tricky to see how much of a rise we get. I am doubting it will send the inr up by very much. I am betting the difference would be around 0.5 for 75grams of licorice which is about 1/4 of a regular packet., any more licorice than that and you are going to be spending hours punishing the toilet!

Karlynn
August 18th, 2008, 07:37 PM
I'm wondering if any of the various valve companies might want to develop any new test control anticoagulation study groups :D ...
I will volunteer to be in that group. I LOVE black licorice - particularly the Australian kind I buy at Trader Joe's. However, I don't consume a lot of it now as it is not Throw-Down friendly - lots of carbs!

Ross
August 19th, 2008, 01:57 AM
I don't like Black licorice or I'd do the testing.

catwoman
August 20th, 2008, 05:41 AM
OK, I been thinking!...to do this properly I would need to test oneday then come home and consume the licorice then go back and test the next day ( and no greens for dinner that night!)...so maybe this is more suited to someone who has a home test kit. I am quite willing to do it the other way but it will probably be tricky to see how much of a rise we get. I am doubting it will send the inr up by very much. I am betting the difference would be around 0.5 for 75grams of licorice which is about 1/4 of a regular packet., any more licorice than that and you are going to be spending hours punishing the toilet!

I think you'd need to wait more than 1 day and eat licorice for more than just one day.

Would be so nice if we could clone ourselves and do a double-blind test, wouldn't it, to determine exactly what a drug/food/OTC drug/exercise/whatever did to our INR?